Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mama

Valdemar Mitsunori Iwamoto, Vilmar Marques de Oliveira, Fábio Bagnoli, Jose Francisco Rinaldi, Decio Roveda Junior, Maria Antonieta Longo Galvão da Silva, José Mendes Aldrighi

Resumo


Objetive: this study intends to verify the correlation of mammographic breast density and expression level of enzymes aromatase and 17ΒHSD1 in infiltrating ductal carcinoma. Methods: Forty-eight cases were evaluated by mammographic image grading density by ACR BI-RADS® and by tissue micro array (TMA) to expression immunohistochemically screened with anti-aromatase polyclonal antibodies and anti-17βhsd1 monoclonal antibodies. Results: In relation to breast density, in absolute numbers and percentages, we found the following results: in category 1, 17 patients (35.42%), category 2, 17 patients (35.42%), category 3, 6 patients (12 50%) and category 4, 8 patients (16.67%). The aromatase expression was positive in 18 (37.5%). Statistical analysis showed no significant correlation between the expression of aromatase with breast density (p = 0.917). The 17βHSD1 expression was positive in 18 (37.5%). Statistical analysis showed no significant correlation between the expression of 17βHSD1 with breast density (p= 0.666). The no significant correlation between the expression of 17βHSD1 with breast density was found to be unchanged even when the analysis of the proposed subgroups (BMI greater than or less than 25, aged greater or less than 50 years and high or low mammographic density). Statistical analysis showed a significant correlation between the expression of aromatase and 17βHSD1 (p= 0.00048). Conclusion: After analysis of our results we can conclude that there was no positive association between mammographic breast density and expression of enzymes aromatase and 17βHSD1.

Keywords: Aromatase, Breast neoplasms, Mammography, Hydroxysteroid dehydrogenases


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