Clinical, Laboratory, and Morphometric Aspects of Postmenopausal Women with Genitourinary Syndrome Undergoing Fractional Microablative Radiofrequency (FRAXX) Treatment

Abstract

Objective: This study aimed to analyze the effects of microablative fractional radiofrequency (MFRF) on vaginal epithelial morphometry in postmenopausal women with genitourinary syndrome. Method: A prospective clinical study included postmenopausal women who attended five visits to the Climacteric  Clinic of Santa Casa de São Paulo from September 2019 to April 2023. During the visits, biopsies, and MFRF applications were conducted. Histological and morphometric variations between baseline (T0) and after three MFRF applications (T3) were analyzed using a light microscope and Wilcoxon’s test for statistical analysis. Results: Most patients showed a reduction in the menopausal index. Sexual problems and vaginal dryness were the symptoms that most participants showed improvement in. The average vaginal epithelial thickness increased significantly from 0.075 mm at T0 to 0.228 mm at T3 after 90 days of treatment (p < 0.05). Thirteen women showed an average increase of 304% in vaginal epithelial thickness, while three women exhibited a decrease of 32% from T0 to T3. Conclusion: MFRF applications in postmenopausal women resulted in a significant improvement in the clinical aspects of Genitourinary Syndrome and an increase in the thickness of the vaginal epithelium.