Estudo do padrão de melhora da alopecia androgenética em pacientes com uso de microagulhamento associado a minoxidil e/ou plasma rico em plaquetas e mesoterapia / Study of the pattern of improvement in androgenetic alopecia in patients using microneedling associated with minoxidil and/or platelet-rich plasma and mesotherapy

Autores

  • Mario Henrique Quim Ferreira Universidade do Oeste Paulista (UNOESTE). Faculdade de Medicina. Presidente Prudente – SP – Brasil
  • Isabella Bessegatto Rodrigues Universidade do Oeste Paulista (UNOESTE). Faculdade de Medicina. Presidente Prudente – SP – Brasil
  • Marcella Bessegatto Rodrigues Universidade do Oeste Paulista (UNOESTE). Faculdade de Medicina. Presidente Prudente – SP – Brasil

DOI:

https://doi.org/10.26432/1809-3019.2021.66.038

Resumo

Resumo

Introdução: a alopécia ligada a fatores hormonais androgênicos é algo que há muito tempo tem sido alvo de estudos e aplicações de conhecimento científico em todo mundo. Este padrão de perda capilar, principalmente ligada ao sexo masculino dispõe de terapias que atualmente se limitam à interrupção da queda de fios com leve progressão de crescimento em alguns casos. Neste tocante, uma nova técnica de microagulhamento, com ou sem terapias adjuvantes, associado a métodos já consagradas como minoxidil tem levado o tratamento desta alteração estética para melhores níveis de resultado. Objetivo: conduzir uma investigação sobre os resultados atuais de pesquisas que envolvam o microagulhamento associado ao uso de Minoxidil, plasma rico em plaquetas e/ou mesoterapia. Metodologia: foram feitas pesquisas no banco de dados da PubMed e Scielo em abril de 2021 buscando-se os termos “minoxidil AND microneedling”. Resultados e Discussões: os resultados obtidos têm convergido para a proposta de que a associação do método de rolagem (microagulhamento) com a aplicação tópica do vasodilatador (minoxidil) apresenta um padrão de crescimento capilar nunca alcançado pela terapia convencional disponível, e que, se acrescentar plasma rico em plaquetas e/ou soluções através da mesoterapia, os resultados podem ser ainda mais vantajosos. Conclusão: novos estudos são necessários para abranger as vertentes ainda não elucidadas para o tratamento da alopecia, contudo, os resultados até aqui obtidos são promissores para o sucesso da reposição capilar.

Palavras chave: Microagulhamento, Minoxidil, Alopecia

 

Abstract

Introduction: alopecia linked to androgenic hormonal factors is something that has long been the subject of studies and knowledge applications worldwide. This pattern of hair loss, mainly related to males, has therapies that are currently limited to interruption of hair loss with slight growth progression in some cases. In this regard, a new microneedling technique, with or without adjuvant therapies, associated with well-established methods such as minoxidil has led the treatment of this esthetic alteration to better levels of results. Objective: to conduct an investigation into the current results of research involving microneedling associated with the use of Minoxidil, platelet-rich plasma and/or mesotherapy. Methodology: searches were conducted in the PubMed and Scielo database in April 2021, searching for the terms “minoxidil AND microneedling”. Results and Discussions: the results obtained have converged to the proposal that the association of the rolling method (microneedling) with the topical application of a vasodilator (minoxidil) presents a pattern of hair growth never achieved by the available conventional therapy, and that, if added platelet-rich plasma and/or solutions through mesotherapy, the results can be even more advantageous. Conclusion: further studies are needed to cover aspects that have not yet been elucidated for the treatment of alopecia, however, the results obtained so far are promising for the success of hair replacement.

Keywords: Microneedling, Minoxidil, Alopecia

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Downloads

Não há dados estatísticos.

Referências

Steiner D, Bartholomei S. Alopecia na mulher. Rev Bras Med. 2000; 57(05).

Rossi A, Anzalone A, Fortuna MC, Caro, G, Garelli V, Pranteda G, Carlesimo M. Multi"therapies in androgenetic alopecia: Review and clinical experiences. Dermat Therap. 2016; 29(6): 424-432.

Varothai S, Bergfeld WF. Androgenetic Alopecia: An Evidence-Based Treatment Update. American Journal Of Clinical Dermatology. Springer Nature. 22 maio 2014; 15(3):217-230.

Marques CC, Steiner D, Miquelin GM, Colferai MMT, Gatti EF. Estudo comparativo e randomizado do Plasma Rico em Plaquetas na Alopecia Androgenética Masculina. Surg Cosmet Dermat. 2016; 8(4).

Fertig RM, Gamret AC, Cervantes J, Tosti A. Microneedling for the treatment of hair loss?. J Europ Acad Dermat Venereol. 2018 32(4), 564-569.

Prie BE, Iosif L, Tivig I, Stoian I, Giurcaneanu C. Oxidative stress in androgenetic alopecia. Journal of medicine and life. 2016; 9(1): 79.

Blumeyer A, Tosti A, Messenger A, Reygagne, P, Del Marmol V, Spuls P, et al. Evidence"based (S3) guideline for the treatment of androgenetic alopecia in women and in men. JDDG: J Deutsch Dermat Gesellschaft. 2011; 9: 1-57.

Filbrandt R, Rufaut N, Jones L, Sinclair R. Primary cicatricial alopecia: diagnosis and treatment. Canad Med Assoc J. 2013; 185(18): 1579-1585.

Bartsch G, Rittmaster R, Klocker H. Dihydrotestosterone and the concept of 5α-reductase inhibition in human benign prostatic hyperplasia. World journal of urology. 2002; 19(6): 413-425.

Chiriacò G, Cauci S, Mazzon G, Trombetta C. An observational retrospective evaluation of 79 young men with long"term adverse effects after use of finasteride against androgenetic alopecia. Andrology. 2016; 4(2): 245-250

Kaliyadan F, Nambiar A, Vijayaraghavan S. Androgenetic alopecia: an update. Ind J Dermat Venereol Leprol. 2013; 79(5): 613.

Mulinari-Brenner F, Soares IF. Alpecia androgenética masculina: uma atualização. Rev Cienc Med. 2012; 18(3):153-161.

Singh A, Yadav S. Microneedling: advances and widening horizons. Indian Dermat On J. 2016; 7(4): 244.

Lima EVDA, Lima MDA., Takano D. Microagulhamento: estudo experimental e classificação de injúria provocada. Surg Cosmet Dermat. 2013; 5(2):1104.

Vermohlem AB, Marques AAF. Microagulhamento associado a fator de crescimento e minoxidil no tratamento da alopecia androgenética: revisão de literatura. Tecnol Cosmet Estetic - Pedra Branca. 2018.

Contin LA. Alopecia androgenética masculina tratada com microagulhamento isolado e associado a minoxidil injetável pela técnica de microinfusão de medicamentos pela pele. Surg Cosmet Dermat. 2016; 8(2): 158-161.

Strazzulla LC, Avila L, Sicco KL, Shapiro J. An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata. Journal of Investigative Dermatology.2017; 19(1): 21-24.

Lima AA, Souza TH, Grignoli LCE. Os benefí­cios do microagulhamento no tratamento das disfunções estéticas. Rev Cient FHO | UNIARARAS. 2015; 3(1): 92-99.

Kalil CLPV, Frainer RH, Dexheimer LS, Tonoli RE, Boff AL. Tratamento das cicatrizes de acne com a técnica de microagulhamento e drug delivery. Surgical & Cosmetic Derm. 2015; 7(2).

Silva LBP, Santos BA. Uso do Laser de baixa intensidade no tratamento da Alopecia Androgenética: Uma Revisão Bibliográfica. ID On: Rev Mult Psicol. 2018; 12(40): 1065-1081.

Galvão TF, Pansani TDSA, Harrad D. Principais itens para relatar Revisões sistemáticas e Meta-análises: A recomendação PRISMA. Epid Serv Saúd. 2015; 24: 335-342.

Santos CMDC, Pimenta CADM, Nobre MRC. The PICO strategy for the research question construction and evidence search. Rev Latino-Americ Enferm. 2007; 15(3): 508-511.

Kumar MK, Inamadar AC, Palit A. A randomized controlled, single-observer blinded study to determine the efficacy of topical minoxidil plus microneedling versus topical minoxidil alone in the treatment of androgenetic alopecia. J Cutan Aesth Surg. 2018; 11(4): 211.

Dhurat R, Mathapati S. Response to microneedling treatment in men with androgenetic alopecia who failed to respond to conventional therapy. Indian J Dermat. 2015; 60(3): 260.

Dhurat R, Sukesh MS, Avhad G, Dandale A, Pal A, Pund, P. A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study. Intern J Trichol. 2013; 5(1): 6.

Faghihi G, Nabavinejad S, Mokhtari F, Fatemi Naeini F, Iraji F. Microneedling in androgenetic alopecia; comparing two different depths of microneedles. J Cosm Dermat. 2021; 20(4): 1241-1247.

Fujita J. Favorable effects of microneedling on long"standing androgenetic alopecia in an elderly man: A case report. J Cosm Derm. 2021; 20(2): 588-590.

Sohng C, Lee EH, Woo SK, Kim JY, Park KD, Lee SJ, Lee WJ. Usefulness of home"use microneedle devices in the treatment of pattern hair loss. J Cosm Dermat. 2021; 20(2): 591-596.

Gajjar PC, Mehta HH, Barvaliya M, Sonagra B. Comparative study between mesotherapy and topical 5% minoxidil by dermoscopic evaluation for androgenic alopecia in male: A randomized controlled trial. Inter J Trichol. 2019; 11(2): 58.

Jha AK, Vinay K, Zeeshan M, Roy PK, Chaudhary RKP, Priya A. Platelet"rich plasma and microneedling improves hair growth in patients ofandrogenetic alopecia when used as an adjuvant to minoxidil. J Cosmetic Dermat. 2019.

Shah KB, Shah AN, Solanki RB, Raval RC. A comparative study of microneedling with platelet-rich plasma plus topical minoxidil (5%) and topical minoxidil (5%) alone in androgenetic alopecia. Inter J Trichol. 2017; 9(1): 14.

Tosti A, Duque-Estrada B. Treatment strategies for alopecia. Expert Opin Pharmacother. 2009; 10: 1017–26.

Mella JM, Perret MC, Manzotti M, Catalano HN, Guyatt G. Efficacy and safety of finasteride therapy for androgenetic alopecia: A systematic review. Arch Dermatol. 2010; 146: 1141–50.

Schweiger ES, Boychenko O, Bernstein RM. Update on the pathogenesis, genetics and medical treatment of patterned hair loss. J Drugs Dermatol. 2010;9:1412–9.

Jeong K, Lee YJ, Kim JE, Park YM, Kim BJ, Kang H. Repeated microneedle stimulation induce the enhanced expression of hair-growth-related genes. Int J Trichology. 2012;4:117.

Kim BJ, Lim YY, Kim HM, Lee YW, Won CH, Huh CH, et al. Hair follicle regeneration in mice after wounding by microneedle roller. Int J Trichology. 2012;4:117.

Wipf A, Boysen N, Hordinsky MK, Dando EE, Sadick N, Farah RS. The rise of transcutaneous drug delivery for the management of alopecia: A review of existing literature and an eye towards the future. J Cosmetic Laser Therapy. 2019; 1-8.

Almohanna HM, Perper M, Tosti A. Safety concerns when using novel medications to treat alopecia. Exp opin drug safety. 2018; 17(11): 1115-1128.

Yu AJ, Luo YJ, Xu XG, Bao LL, Tian T, Li Z. et al. A pilot split"scalp study of combined fractional radiofrequency microneedling and 5% topical minoxidil in treating male pattern hair loss. Clinic Experim Derm. 2018; 43(7): 775-781.

Publicado

2021-11-22

Edição

Seção

ARTIGO DE REVISÃO