Usos do G-CSF no tratamento da COVID-19 e o papel de fatores de crescimento hematopoiético na fisiopatologia da doença: uma revisão sistemática / G-CSF’s uses on COVID-19 treatment and the role of hematopoietic growth factors on the disease pathophysiology: a systematic review

Authors

  • Tatiana Carvalho Marques Centro Universitário Lusíada - UNILUS. Faculdade de Ciências Médicas de Santos. Curso de Graduação em Medicina. Santos – SP – Brasil https://orcid.org/0000-0001-6578-0261
  • Eliana Claudia Perroud Morato Ferreira Centro Universitário Lusíada - UNILUS. Departamento de Hematologia e Hemoterapia. Santos – SP - Brasil https://orcid.org/0000-0001-7150-1126

DOI:

https://doi.org/10.26432/1809-3019.2023.68.005

Keywords:

SARS-CoV-2, Granulocyte Colony-Stimulating Factor, COVID-19, Filgrastim

Abstract

Introduction: Hematopoiesis is controlled by specific growth factors, and their isolation leads to a new type of therapeutic agents such as the granulocyte colony-stimulating fator (G-CSF), that acts of neutrophils. Aims: In light of the importance of this drug and COVID-19’s pandemic, this review aims to discuss the possible benefits and risks of G-CSFs uses on COVID-19’s treatment, in addition to the role of hematopoietic growth factor on the disease’s pathophysiology. Method: A systematic review was made using PubMed, Scielo and BIREME as databases, using the keywords: COVID-19 and Granulocyte Colony-stimulating Factor. Results: On Biblioteca Virtual em Saúde (BIREME), 10 papers were selected. No study was retrieved from Scielo. At PubMed database, only 1 paper fit the inclusion criteria. Conclusion: After literature review and analysis, it was not possible to verify the efficacy of G-CSF on COVID-19’s treatment, even though it seems to be safe and with little side effects.

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Published

2023-06-12

Issue

V. 68 (2023): Jan/Dez

Section

ARTIGO DE REVISÃ0 SISTEMÁTICA

License

Copyright (c) 2023 Tatiana Carvalho Marques, Eliana Claudia Perroud Morato Ferreira

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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